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Anti-Phospho-p53-S15 Antibody
Catalog #: 144-50644
Phospho-p53-S15 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P04637 |
| Gene Id | 7157 |
| Gene Symbols | TP53 |
| Protein Name / Synonyms | TP53, BCC7, LFS1, P53, TRP53, tumor protein p53 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IF, IP |
| Research Area | Apoptosis, Cancer, p53 Signaling, Autophagy, DNA Damage |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Dilutions
WB 1:500 - 1:2000; IF 1:50 - 1:200; IP 1:50 - 1:100
Format
Calculated MW
23-43kDa
Observed MW
55kDa
Immunogen
A synthetic phosphorylated peptide around S15 of human p53 (NP_000537.3).
Modification
Phospho S15
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.