Anti-Phospho-p53-S6 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P04637
Gene Id	7157
Gene Symbols	Tp53
Protein Name / Synonyms	P53, BCC7, LFS1, BMFS5, TRP53
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting
Research Area	Apoptosis, Cancer, p53 Signaling, Autophagy, DNA Damage
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Dilutions

WB 1:500 - 1:2000

Format

Calculated MW

43kDa

Observed MW

Immunogen

A phospho specific peptide corresponding to residues surrounding S6 of human TP53.

Modification

Storage

Store at -20°. Avoid freeze / thaw cycles.

Expiration:

12 months from the date of shipment when stored properly.

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