Rabbit Anti-Phospho-PDGFR-Y579 Antibody, 400 µl
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | This Phospho-PDGFR-Y579 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y579 of human PDGFR. |
| Host Species | Rabbit |
| Accession Number | P09619, Q05030, P05622, P26619, P20786, P26618, P16234, Q9DE49, Q9PUF6 |
| Gene Id | 5159 |
| Gene Symbols | PDGFRB |
| Protein Name / Synonyms | Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1, CD140b, PDGFRB, PDGFR, PDGFR1 |
| Clonality | Polyclonal |
| Isotype | IgG, Rabbit |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Recommended Applications | IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
NCBI Accession #
NP_002600.1
Antigen Source
Human
Antigen Type
Synthetic Peptide
Calculated Molecular Weight (Da)
123968
IHC-P (1:50~100)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration
12 months from the date of shipment when stored properly.
Introduction
PDGFR is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene for this protein is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia.