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Anti-Phospho-ZAP70-Y493 Antibody
Catalog #: 144-50701
Phospho-ZAP70-Y493 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P43403 |
| Gene Id | 7535 |
| Gene Symbols | ZAP70 |
| Protein Name / Synonyms | ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70, tyrosine-protein kinase ZAP-70 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IHC |
| Research Area | Inflammation, Autoimmune Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Dilutions
WB 1:2000 - 1:5000; IHC 1:50 - 1:100
Format
Calculated MW
35kDa/55kDa/69kDa
Observed MW
70kDa
Immunogen
A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70
Modification
Phospho Y493
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.