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Anti-PI3 Kinase p85 beta Antibody
Catalog #: 102-26553
Mouse Anti-PI3 Kinase p85 beta Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Mouse |
| Accession Number | O00459 |
| Gene Id | 5296 |
| Gene Symbols | PIK3R2 |
| Protein Name / Synonyms | p |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting |
| Research Area | Phosphorylation, Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of PI3 Kinase p85 beta in C6,K562,MCF7,U87MG,HCT116,3T3 and Hela cell lysates using PI3 Kinase p85 beta mouse mAb (1:1000 diluted).Predicted band size:85KDa.Observed band size:85KDa.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.