Anti-PI3CKG (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P48736
Gene Id	5294
Gene Symbols	PIK3CG
Protein Name / Synonyms	PI3CKG (C-term)
Clonality	Polyclonal
Preparation	This PI3CKG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1041-1070 amino acids from the C-terminal region of human PI3CKG.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Angiogenesis, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

Specificity

Other Names

PIK3CG; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; p120-PI3K

NCBI Accession #

NP_001269355.1;NP_001269356.1;NP_002640.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

126454

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of anti-PI3CKG Antibody (C-term) Pab (Cat# 102-17852) in Hela cell line lysates (35ug/lane). PI3CKG (arrow) was detected using the purified Pab.
	Western blot analysis of anti-PIK3CG Antibody (C-term) Pab (Cat# 102-17852) in 293 cell line lysates transiently transfected with the PIK3CG gene (2ug/lane). PIK3CG(arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human muscle tissue tissue reacted with PI3CKG antibody (C-term)(Cat# 102-17852), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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