This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

IF 1:50 - 1:200

Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_006090.2).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.