Anti-PML Sumoylation Site Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P29590
Gene Id	5371
Gene Symbols	PML
Protein Name / Synonyms	Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, PML, MYL, PP8675, RNF71, TRIM19
Clonality	Polyclonal
Clone	RB2570
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, IHC-P, IF, FC
Research Area	Angiogenesis, Post-Translational Modifications
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).

Other Information

NCBI Accession #

NP_002666.1;NP_150241.2;NP_150242.1;NP_150243.2;NP_150247.2;NP_150249.1;NP_150250.2;NP_150252.1;NP_150253.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Calculated Molecular Weight (Da)

97551

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of anti-PML Sumoylation Site Antibody (Cat. 102-25400) in Hela cell line lysates (35ug/lane). PML (arrow) was detected using the purified Pab.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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