Anti-PPARD (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q03181
Gene Id	5467
Gene Symbols	PPARD
Protein Name / Synonyms	PPARD (C-term)
Clonality	Polyclonal
Preparation	This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-394 amino acids from the C-terminal region of human PPARD.
Concentration (lot specific)	0.430 mg/ml
Recommended Applications	Western Blotting, FC
Research Area	Cardiovascular Disease, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Specificity

Other Names

PPARD; NR1C2; PPARB; Peroxisome proliferator-activated receptor delta; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta

NCBI Accession #

NP_001165289.1;NP_001165290.1;NP_001165291.1;NP_006229.1;NP_803184.1

Other Accession #

NP_803184.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49903

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	PPARD Antibody (C-term) (Cat# 102-11320) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPARD antibody detected the PPARD protein (arrow).
	PPARD Antibody (C-term) (Cat# 102-11320) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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