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Anti-PPM1D (Center) Antibody
Catalog #: 102-12202
Rabbit Anti-Human PPM1D (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | O15297 |
| Gene Id | 8493 |
| Gene Symbols | PPM1D |
| Protein Name / Synonyms | PPM1D (Center) |
| Clonality | Polyclonal |
| Preparation | This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D. |
| Concentration (lot specific) | 0.490 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Specificity
Predicted Reactivity
Mouse
Other Names
PPM1D; WIP1; Protein phosphatase 1D; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1
NCBI Accession #
NP_003611.1
Other Accession #
Q9QZ67; NP_003611.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
66675
Recommended Dilutions
WB: 1:1000
 | PPM1D Antibody (Center) (Cat# 102-12202) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PPM1D antibody detected the PPM1D protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.