3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-PRDM6 (N-term) Antibody
Catalog #: 102-12476
Rabbit Anti-Human PRDM6 (N-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9NQX0 |
| Gene Id | 93166 |
| Gene Symbols | PRDM6 |
| Protein Name / Synonyms | PRDM6 (N-term) |
| Clonality | Polyclonal |
| Preparation | This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6. |
| Concentration (lot specific) | 0.350 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).
Specificity
Other Names
PRDM6; PFM3; Putative histone-lysine N-methyltransferase PRDM6; PR domain zinc finger protein 6; PR domain-containing protein 6
NCBI Accession #
NP_001129711.1
Other Accession #
NP_001129711.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
64452
Recommended Dilutions
WB: 1:1000
 | PRDM6 Antibody (N-term) (Cat# 102-12476) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PRDM6 antibody detected the PRDM6 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.