Anti-PSMA7 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O14818
Gene Id	5688
Gene Symbols	PSMA7
Protein Name / Synonyms	PSMA7 (Center)
Clonality	Polyclonal
Preparation	This PSMA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the Central region of human PSMA7.
Concentration (lot specific)	0.470 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA7 is a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension.

Specificity

Predicted Reactivity

Rat, Bovine, Xenopus

Other Names

PSMA7; HSPC; Proteasome subunit alpha type-7; Proteasome subunit RC6-1; Proteasome subunit XAPC7

NCBI Accession #

NP_002783.1

Other Accession #

P48004; Q9Z2U0; Q3ZBG0; Q9PVQ1; Q9PVY6

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

27887

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of PSMA7 Antibody (Center) (Cat# 102-17973) in mouse spleen tissue lysates (35ug/lane). PSMA7 (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PSMA7 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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