Anti-PTPN22 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q9Y2R2
Gene Id	26191
Gene Symbols	PTPN22
Protein Name / Synonyms	PTPN22, LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8, tyrosine-protein phosphatase non-receptor type 22
Clonality	Polyclonal
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting
Research Area	Cancer, Inflammation, Autophagy, Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Dilutions

WB 1:500 - 1:2000

Format

Calculated MW

20kDa/75kDa/78kDa/85kDa/88kDa/91kDa

Observed MW

107kDa

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PTPN22 (NP_036543.4).

Modification

Unmodified

Storage

-20°C

Images

Western blot analysis of extracts of various cell lines, using PTPN22 antibody (144-60569) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
Western blot - PTPN22 antibody (144-60569)

Expiration:

12 months from the date of shipment when stored properly.

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