Anti-PTPRC (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P08575
Gene Id	5788
Gene Symbols	PTPRC
Protein Name / Synonyms	PTPRC (N-term)
Clonality	Polyclonal
Preparation	This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.
Concentration (lot specific)	0.300 mg/ml
Recommended Applications	Western Blotting, FC
Research Area	Cancer, Inflammation, Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq].

Specificity

Other Names

PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; T200; CD_antigen=CD45; Flags: Precursor

NCBI Accession #

NP_002829.3;NP_563578.2

Other Accession #

NP_563578.1; NP_002829.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

147254

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	PTPRC Antibody (N-term) (Cat# 102-11219) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PTPRC antibody detected the PTPRC protein (arrow).
	PTPRC Antibody (N-term) (Cat# 102-11219) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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