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Anti-RB1 (Center S249) Antibody
Catalog #: 102-22478
Rabbit Anti-RB1 (Center S249) Antibody, 400 µl
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P06400|NP_000312.2 |
| Gene Id | 5925 |
| Gene Symbols | RB1 |
| Protein Name / Synonyms | Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1 |
| Clonality | Polyclonal |
| Clone | RB36870 |
| Isotype | Kappa, Rabbit |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Other Information
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated Molecular Weight (Da)
106159
Expiration:
12 months from the date of shipment when stored properly.