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Anti-Retinoblastoma / Rb Antibody
Catalog #: 188-11195
Mouse anti-Human/Mouse Retinoblastoma / Rb Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Mouse |
| Accession Number | P06400 |
| Gene Id | 5925 |
| Gene Symbols | RB1 |
| Protein Name / Synonyms | Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110) |
| Immunogen | A human recombinant protein was used as the immunogen for this Rb antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Western Blotting: 0.5-1ug/ml IP: 1-2ug/500ug protein lysate IHC (FFPE): 1-2ug/ml for 30 min at RT |
| Domain / Region / Terminus | Nuclear |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
Storage
The Rb antibody (with azide) can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Expiration:
12 months from the date of shipment when stored properly.