Anti-RFXANK (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O14593
Gene Id	8625
Gene Symbols	RFXANK
Protein Name / Synonyms	RFXANK (Center)
Clonality	Polyclonal
Preparation	This RFXANK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human RFXANK.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

Specificity

Other Names

RFXANK; ANKRA1; RFXB; DNA-binding protein RFXANK; Ankyrin repeat family A protein 1; Regulatory factor X subunit B; Regulatory factor X-associated ankyrin-containing protein

NCBI Accession #

NP_001265656.1;NP_001265657.1;NP_003712.1;NP_604389.1

Other Accession #

NP_604389.1; NP_003712.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

28102

Recommended Dilutions

WB: 1:1000

RFXANK Antibody (Center) (Cat# 102-12869) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the RFXANK antibody detected the RFXANK protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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