Anti-S100B/S-100 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P04271
Gene Id	6285
Gene Symbols	S100B
Protein Name / Synonyms	S100B/S-100 (Center)
Clonality	Polyclonal
Preparation	This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the Central region of human S100B/S-100.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Research Area	Neuroscience
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine, Rabbit

Other Names

S100B; Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

NCBI Accession #

NP_006263.1

Other Accession #

P04631; Q6YNR6; P50114; P02638; NP_006263.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

10713

Recommended Dilutions

WB: 1:1000

S100B/S-100 Antibody (Center) (Cat# 102-12731) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the S100B/S-100 antibody detected the S100B/S-100 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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