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Anti-SCN1B (N-term) Antibody
Catalog #: 102-10728
Rabbit Anti-SCN1B (N-Term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q07699 |
| Gene Id | 6324 |
| Gene Symbols | SCN1B |
| Protein Name / Synonyms | SCN1B (N-Term) |
| Clonality | Polyclonal |
| Preparation | This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, FC |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificity
Predicted Reactivity
Rat, Bovine, Rabbit
Other Names
SCN1B; Sodium channel subunit beta-1
NCBI Accession #
NP_001028.1;NP_950238.1
Other Accession #
Q00954; P53788; P97952; Q17QN4; NP_950238.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
24707
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; FC: 1:10-50
 | SCN1B Antibody (N-Term) (Cat# 102-10728) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SCN1B antibody detected the SCN1B protein (arrow). |
 | SCN1B Antibody (N-Term) (Cat# 102-10728) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | SCN1B Antibody (N-Term) (Cat# 102-10728) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.