Anti-SETDB1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q15047
Gene Id	9869
Gene Symbols	SETDB1
Protein Name / Synonyms	SETDB1 (C-term)
Clonality	Polyclonal
Preparation	This SETDB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1193-1225 amino acids from the C-terminal region of human SETDB1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.

Specificity

Predicted Reactivity

Mouse, Zebrafish, Xenopus

Other Names

SETDB1; KIAA0067; KMT1E; Histone-lysine N-methyltransferase SETDB1; ERG-associated protein with SET domain; Histone H3-K9 methyltransferase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1

NCBI Accession #

NP_001138887.1;NP_001230420.1;NP_036564.3

Other Accession #

Q08BR4; Q6INA9; O88974

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

143157

Recommended Dilutions

WB: 1:1000

	Western blot analysis of anti-SETDB1 Pab(Cat# 102-10782) in Ramos cell line lysate (35ug/lane). SETDB1(arrow) was detected using the purified Pab.
	Western blot analysis of SETDB1(arrow) using rabbit polyclonal SETDB1 Antibody (C-term) (Cat# 102-10782). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SETDB1 gene (Lane 2) (Origene Technologies).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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