Anti-SFTPC (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P11686
Gene Id	6440
Gene Symbols	SFTPC
Protein Name / Synonyms	SFTPC (C-term)
Clonality	Polyclonal
Preparation	This SFTPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human SFTPC.
Concentration (lot specific)	0.490 mg/ml
Recommended Applications	IHC-P, Western Blotting, IF
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Specificity

Other Names

SFTPC; SFTP2; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SP5

NCBI Accession #

NP_001165828.1;NP_001165881.1;NP_003009.2

Other Accession #

NP_001165828.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

21053

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	SFTPC Antibody (C-term) (Cat# 102-12096) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SFTPC antibody detected the SFTPC protein (arrow).
	SFTPC Antibody (C-term) (Cat# 102-12096)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SFTPC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of SFTPC Antibody (C-term)(Cat# 102-12096) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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