Anti-SIGLEC6 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O43699
Gene Id	946
Gene Symbols	SIGLEC6
Protein Name / Synonyms	SIGLEC6 (N-term)
Clonality	Polyclonal
Preparation	This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of human SIGLEC6.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Specificity

Other Names

SIGLEC6; CD33L; CD33L1; OBBP1; Sialic acid-binding Ig-like lectin 6; CD33 antigen-like 1; CDw327; Obesity-binding protein 1; CD_antigen=CD327; Flags: Precursor

NCBI Accession #

NP_001171018.1;NP_001171019.1;NP_001171020.1;NP_001236.4;NP_942142.3;NP_942143.3

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49913

Recommended Dilutions

WB: 1:1000

Western blot analysis of SIGLEC6 Antibody (N-term) (Cat# 102-12909) in NCI-H460 cell line lysates (35ug/lane). SIGLEC6 (arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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