Anti-Smad2 Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Mouse
Accession Number	Q15796
Gene Id	4087
Gene Symbols	SMAD2
Protein Name / Synonyms	hMAD 2;hMAD-2;hSMAD2;JV18 1;JV18;JV18;JV18-1;JV181;MAD;MAD;MAD homolog 2;MAD Related Protein 2;Mad-related protein 2;MADH2;MADR2;MGC22139;MGC34440;Mothers Against Decapentaplegic Homolog 2;Mothers Against Decapentaplegic Homolog 2;mothers against DPP homolog 2;OTTHUMP00000163489;Sma and Mad related protein 2;SMAD 2;SMAD;SMAD family member 2;SMAD, mothers against DPP homolog 2;SMAD2;SMAD2_HUMAN.
Clonality	Monoclonal
Recommended Applications	Western Blotting, ICC
Research Area	Cardiovascular Disease, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Other Information

Antigen Type

Recombinant Protein

Images

WB (1:500)

Western blot detection of Smad2 in Hela,A431,Jurkat and K562 cell lysates using Smad2 mouse mAb (1:500 diluted).Predicted band size:60KDa.Observed band size:60KDa.

ICC (1:100)

Immunocytochemistry staining of HeLa cells fixed with 1% Paraformaldehyde and using Smad2 mouse mAb (dilution 1:100).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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