Anti-SOCS3 (Ascites) Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Mouse
Accession Number	O14543\|NP_003946.3
Gene Id	9021
Gene Symbols	SOCS3
Protein Name / Synonyms	Suppressor of cytokine signaling 3, SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3, SOCS3, CIS3, SSI3
Clonality	Monoclonal
Clone	532CT13.5.3
Isotype	IgM
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Other Information

NCBI Accession #

NP_003946.3

Antigen Type

Recombinant Protein

Format

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Calculated Molecular Weight (Da)

24770

Antigen Source

Human

Images

WB (1:500~1600)

SOCS3 Antibody (Cat. #102-20086) western blot analysis in HepG2 cell line lysates (35?g/lane).This demonstrates the SOCS3 antibody detected the SOCS3 protein (arrow).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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