Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

WB 1:500 - 1:2000; IHC 1:50 - 1:100

Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.