Anti-STAT2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P52630
Gene Id	6773
Gene Symbols	STAT2
Protein Name / Synonyms	STAT2 (C-term)
Clonality	Polyclonal
Preparation	This STAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-851 amino acids from the C-terminal region of human STAT2.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

Specificity

Other Names

STAT2; Signal transducer and activator of transcription 2; p113

NCBI Accession #

NP_005410.1;NP_938146.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

97916

Recommended Dilutions

IHC: 1:50-100; WB: 1:1000

	STAT2 Antibody (C-term) (Cat# 102-12782) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STAT2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Western blot analysis of STAT2 Antibody (C-term) (Cat# 102-12782) in K562 cell line lysates (35ug/lane). STAT2(arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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