The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

WB 1:500 - 1:2000

A synthetic peptide corresponding to a sequence within amino acids 600-700 of human STAT4 (NP_001230764.1).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.