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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P48025|Q64725|F1N9Y5|NP_035648.2 |
| Gene Id | 20963 |
| Gene Symbols | Syk |
| Protein Name / Synonyms | Tyrosine-protein kinase SYK, Spleen tyrosine kinase, Syk, ptk72, Sykb |
| Clonality | Polyclonal |
| Clone | RB35418 |
| Isotype | Kappa, Rabbit |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Phosphorylates USP25 and regulates its intracellular levels (By similarity).
Other Information
NCBI Accession #
NP_001185906.1;NP_035648.2
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated Molecular Weight (Da)
71376
Antigen Source
Mouse
Images
WB (1:1000)
Mouse Syk Antibody (Center) (Cat. #102-22188) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the Syk antibody detected the Syk protein (arrow).
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.