Anti-TEAD2 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q15562
Gene Id	8463
Gene Symbols	TEAD2
Protein Name / Synonyms	TEAD2 (Center)
Clonality	Polyclonal
Preparation	This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Specificity

Other Names

TEAD2; TEF4; Transcriptional enhancer factor TEF-4; TEA domain family member 2

NCBI Accession #

NP_001243587.1;NP_001243588.1;NP_001243589.1;NP_001243590.1;NP_001243591.1;NP_003589.1

Other Accession #

P48301; NP_003589.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49243

Recommended Dilutions

WB: 1:1000

	TEAD2 Antibody (Center) (Cat# 102-12407) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).
	TEAD2 Antibody (Center) (Cat# 102-12407) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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