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Anti-TFEB (Center) Antibody
Catalog #: 102-14091
Rabbit Anti-Human TFEB (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P19484 |
| Gene Id | 7942 |
| Gene Symbols | TFEB |
| Protein Name / Synonyms | TFEB (Center) |
| Clonality | Polyclonal |
| Preparation | This TFEB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human TFEB. |
| Concentration (lot specific) | 0.440 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Specificity
Predicted Reactivity
Mouse
Other Names
TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35
NCBI Accession #
NP_001161299.2;NP_001258872.1;NP_001258873.1;NP_001258874.1;NP_009093.1
Other Accession #
Q9R210; NP_009093.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
52865
Recommended Dilutions
WB: 1:1000
 | TFEB Antibody (Center) (Cat# 102-14091) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TFEB antibody detected the TFEB protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.