Anti-TGFB2 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P61812
Gene Id	7042
Gene Symbols	TGFB2
Protein Name / Synonyms	TGFB2
Clonality	Monoclonal
Preparation	This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Angiogenesis, Cardiovascular Disease, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Specificity

Other Names

TGFB2; Transforming growth factor beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; Polyergin

NCBI Accession #

NP_001129071.1;NP_003229.1

Other Accession #

NP_001129071.1; NP_003229.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

47748

Recommended Dilutions

IHC: 1:10-50; IF: 1:10-50; WB: 1:100-1000

	TGFB2 Antibody (Cat# 102-10122)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
	TGFB2 Antibody (Cat# 102-10122)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of TGFB2 Antibody (Cat# 102-10122) with A549 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
	TGFB2/MB10181 antibody (Cat# 102-10122) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TGFB2/MB10181 antibody detected the TGFB2/MB10181 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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