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Anti-TIMP2 Antibody
Catalog #: 188-11141
Mouse anti-Human/Mouse/Rat TIMP2 Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | P16035 |
| Gene Id | 7077 |
| Gene Symbols | TIMP2 |
| Protein Name / Synonyms | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) |
| Immunogen | An amino acid sequence from the N-terminal region of the human protein was used as the immunogen for this TIMP2 antibody. |
| Isotype | Kappa, IgG2a |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | IHC (FFPE): 0.5-1ug/ml for 30 min at RT Western Blotting: 0.5-1ug/ml IF: 1-2ug/ml |
| Domain / Region / Terminus | Cytoplasmic, cell surface, secreted |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases 2 (TIMP2). It is closely related to TIMP1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP9 or gelatinase B). TIMP2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Storage
Store the TIMP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.