Anti-TM173 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q86WV6
Gene Id	340061
Gene Symbols	TMEM173
Protein Name / Synonyms	TM173 (C-term)
Clonality	Polyclonal
Preparation	This TM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human TM173.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, FC
Research Area	Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Specificity

Other Names

TMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Stimulator of interferon genes protein

NCBI Accession #

NP_938023.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

42193

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	Western blot analysis of lysate from U-937 cell line, using TM173 Antibody (C-term)(Cat# 102-18377). 102-18377 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
	TM173 Antibody (C-term) (Cat# 102-18377) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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