Anti-TMEM173 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q86WV6
Gene Id	340061
Gene Symbols	TMEM173
Protein Name / Synonyms	TMEM173, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, transmembrane protein 173
Clonality	Polyclonal
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.09% sodium azide, 50% glycerol, pH 7.3
Recommended Applications	Western Blotting, IHC, IP
Research Area	Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Dilutions

WB 1:500 - 1:2000
IHC 1:50 - 1:100
IP 1:50 - 1:100

Format

Calculated MW

42kDa

Observed MW

39kDa

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 170-379 of human TMEM173 (NP_938023.1).

Modification

Unmodified

Storage

-20°C

Images

Western blot analysis of extracts of various cell lines, using TMEM173 antibody (144-03575) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Western blot - TMEM173 Polyclonal Antibody (144-03575)

Immunohistochemistry of paraffin-embedded mouse heart using TMEM173 antibody (144-03575) at dilution of 1:100 (40x lens).
Immunohistochemistry - TMEM173 Polyclonal Antibody (144-03575)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products