Anti-TNIK (S764) Antibody

Product Description

Specifications

Size	200 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9UKE5
Gene Id	23043
Gene Symbols	TNIK
Protein Name / Synonyms	TRAF2 and NCK-interacting protein kinase, 2.7.11.1, TNIK, KIAA0551
Clonality	Polyclonal
Clone	RB59089
Isotype	IgG
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Other Information

Antigen Type

Synthesized Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Calculated Molecular Weight (Da)

154943

Antigen Source

Human

Images

WB (1:500)

All lanes : Anti-TNIK(S764) Antibody at 1:500 dilution Lane 1: Human brain tissue lysate Lane 2: Caco2 whole cell lysate Lane 3: U-2 OS whole cell lysate Lane 4: U-251 MG whole cell lysate Lane 5: Mouse brain tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 155 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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