Anti-TRIM21 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	P19474
Gene Id	6737
Gene Symbols	TRIM21
Protein Name / Synonyms	TRIM21, RNF81, RO52, Ro/SSA, SSA, SSA1, tripartite motif containing 21
Clonality	Polyclonal
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting, IHC, IF
Research Area	Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Dilutions

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Format

Calculated MW

45kDa/54kDa

Observed MW

Refer to figures

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 80-330 of human TRIM21 (NP_003132.2).

Modification

Unmodified

Storage

-20°C

Images

Immunohistochemistry of paraffin-embedded mouse heart using TRIM21 antibody (144-013547) at dilution of 1:100 (40x lens).
Immunohistochemistry - TRIM21 antibody (144-013547)

Immunofluorescence analysis of U2OS cells using TRIM21 antibody (144-013547). Blue: DAPI for nuclear staining.
Immunofluorescence - TRIM21 antibody (144-013547)

Expiration:

12 months from the date of shipment when stored properly.

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