Anti-TTK (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P33981
Gene Id	7272
Gene Symbols	TTK
Protein Name / Synonyms	TTK (N-term)
Clonality	Polyclonal
Preparation	This TTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human TTK.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

Specificity

Predicted Reactivity

Monkey

Other Names

TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase

NCBI Accession #

NP_001160163.1;NP_003309.2

Other Accession #

Q4R945; NP_003309.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

97072

Recommended Dilutions

WB: 1:1000

TTK Antibody (N-term) (Cat# 102-13316) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the TTK antibody detected the TTK protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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