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Anti-UPF1 Antibody
Catalog #: 144-60385
UPF1 Polyclonal Antibody
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q92900 |
| Gene Id | 5976 |
| Gene Symbols | UPF1 |
| Protein Name / Synonyms | UPF1, HUPF1, NORF1, RENT1, pNORF1, smg-2, UPF1, RNA helicase and ATPase |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IHC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IHC 1:50 - 1:200
Format
Calculated MW
123kDa/124kDa
Observed MW
Refer to figures
Immunogen
Synthetic peptide of human UPF1
Modification
Unmodified
Storage
-20°C
Images
Immunohistochemistry of paraffin-embedded human liver cancer using UPF1 antibody (144-013541) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using UPF1 antibody (144-013541) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using UPF1 antibody (144-013541) at dilution of 1:100 (40x lens).
Expiration:
12 months from the date of shipment when stored properly.