Anti-USP8 (C-term C1072) (Ascites) Antibody

Product Description

Specifications

Size	0.1 mL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P40818
Gene Id	9101
Gene Symbols	USP8
Protein Name / Synonyms	USP8 (C-term C1072) (Ascites)
Clonality	Monoclonal
Preparation	This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.
Recommended Applications	Western Blotting
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

Specificity

Predicted Reactivity

Mouse

Other Names

USP8; KIAA0055; UBPY; Ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8

NCBI Accession #

NP_001122082.1;NP_001122083.1;NP_005145.3

Other Accession #

Q80U87; NP_001122082.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

127523

Recommended Dilutions

WB: 1:500-4000

USP8 Antibody (C1072) (Cat# 102-10280) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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