Anti-VEGF Antibody

Vascular endothelial growth factor (VEGF) is a member of the PDGF/VEGF growth factor family, produced by cells that stimulate the growth of new blood vessels. VEGF family includes VEGF-A, B, C, and D isoforms. VEGF-A was called VEGF before other isoforms were discovered. VEGF plays an important role in creating new blood vessels, inducing angiogenesis, vasculogenesis and endothelial cell growth, inhibiting apoptosis, mediating increased vascular permeability, promoting cell migration, etc. VEGF members stimulate cellular responses through binding to tyrosine kinase receptors (VEGFRs) on the cell surface.

The mouse anti-human VEGF antibody specifically detects targets derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat are expected from sequence similarity.

Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilizedantibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.