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Anti-VEGI / TL1A Antibody, Sodium Azide Free
Catalog #: 188-11115-SAF
Mouse anti-Human VEGI / TL1A Antibody [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | O95150 |
| Gene Id | 9966 |
| Gene Symbols | TNFSF15,TL1,VEGI |
| Protein Name / Synonyms | Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand superfamily member 15, secreted form] |
| Immunogen | A full length human recombinant protein was used as the immunogen for this TL1A antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | FACS: 0.5-1ug/10^6 cells IF: 1-2ug/ml Western blot: 1-2ug/ml IHC (FFPE): 1-2ug/ml |
| Domain / Region / Terminus | Cytoplasmic, cell surface, secreted |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.
Storage
Store the TL1A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.