Anti-WHSC2 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9H3P2
Gene Id	7469
Gene Symbols	NELFA
Protein Name / Synonyms	WHSC2 (Center)
Clonality	Polyclonal
Preparation	This WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Specificity

Predicted Reactivity

Mouse

Other Names

WHSC2; NELFA; Negative elongation factor A; Wolf-Hirschhorn syndrome candidate 2 protein

NCBI Accession #

NP_005654.3

Other Accession #

Q8BG30; NP_005654.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57277

Recommended Dilutions

WB: 1:1000

WHSC2 Antibody (Center) (Cat# 102-12662) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the WHSC2 antibody detected the WHSC2 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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