This GAD2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from human GAD2.
Clonality
Monoclonal
Species
Human, Rat
Introduction
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
GAD2 Antibody (Cat# 102-10273) western blot analysis in rat brain tissue lysates (35ug/lane).This demonstrates the GAD2 antibody detected the GAD2 protein (arrow).
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
