IL-15 is produced largely by dendritic cells, monocytes, andstromal cells. The IL-15R complex consists of three chains, IL-15R , IL-2/15Rbeta, and C chains. IL-15 binds the endogenous IL-15R chain expressed by IL-15-producing cells and is trans-presented to the complex of IL-2/15Rbeta and C chains with the signaling capacity expressed on T cells. The recognition of IL-15 by the latter receptor chains leads to the activationof various signaling pathways including JAK1 and 3/STAT5 aswell as PI3K/AKT. IL-15 has diverse functions that include promoting cytotoxicity and maintenance of memory CD8+ T cells as well as proliferation and differentiationof NK and NK T cells.

Always prepare single-use aliquots planning use while receiving package. A small amount of antibody can be kept at 4°C for daily use. For a long storage, recommend to keep them at -20°C after adding an equal volume of glycerol in PBS. It will not lose activity over a year. Minimize freezing and thawing when use.

12 months from the date of shipment when stored properly.

• Liu K, Catalfamo M, Li Y, Henkart PA, Weng NP. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci U S A. 2002.
• Kim HR, Hwang KA, Kang I. Dual roles of IL-15 in maintaining IL-7RalphalowCCR7- memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway. J Immunol. 2007 Nov 15;179(10):6734-40.