This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
Clonality
Monoclonal
Species
Human
Introduction
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Specificity
Predicted Reactivity
Mouse, Rat, Pig
Other Names
LOX; Protein-lysine 6-oxidase; Lysyl oxidase
NCBI Accession #
NP_002308.2
Other Accession #
P16636; P45845; P28301; NP_002308.2
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
46944
Recommended Dilutions
WB: 1:100-500
LOX Antibody (Center) (Cat# 102-10383) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
