This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP.
Clonality
Monoclonal
Species
Human
Introduction
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine
Other Names
MVP; LRP; Major vault protein; Lung resistance-related protein
NCBI Accession #
NP_005106.2;NP_059447.2
Other Accession #
Q62667; Q9EQK5; Q3SYU9; NP_005106.2
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
99327
Recommended Dilutions
WB: 1:100-1600
MVP Antibody (N-term)(Ascites)(Cat# 102-10369) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MVP antibody detected the MVP protein (arrow).
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
