Product Description

Specifications

Size	20 µg, 100 µg
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Specificity	Other species not known
Host Species	Mouse
Accession Number	P11926
Gene Id	4953
Gene Symbols	ODC1
Protein Name / Synonyms	Ornithine decarboxylase (ODC) (EC 4.1.1.17)
Immunogen	Recombinant human ODC-1 protein was used as the immunogen for this antibody.
Isotype	Kappa, IgG1
Purity	Protein G affinity chromatography
Concentration (lot specific)	0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Recommended Applications	FACS: 0.5-1ug/million cells IF: 0.5-1ug/ml Western Blotting: 0.5-1ug/ml IHC (FFPE): 0.5-1ug/ml for 30 minutes at RT (1) Prediluted format: incubate for 30 min at RT (2)
Domain / Region / Terminus	Cytoplasmic
Shipping Type	Blue ice
Storage	≤-20°C

Description

This antibody recognizes a 53kDa protein, identified as the Ornithine Decarboxylase. ODC-1 is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC-1 mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. Activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.