Purified His-tagged VDR protein(Fragment) was used to produced this monoclonal antibody.
Clonality
Monoclonal
Species
Human
Introduction
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Specificity
Other Names
VDR; NR1I1; Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
NCBI Accession #
NP_000367.1;NP_001017535.1;NP_001017536.1
Other Accession #
NP_000367.1
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
48289
Recommended Dilutions
WB: 1:100-500
VDR Antibody (Cat# 102-10314) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the VDR antibody detected the VDR protein (arrow).
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
