Mouse Anti-Smad2 Antibody, 100 µl
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Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | Q15796 |
| Gene Id | 4087 |
| Gene Symbols | SMAD2 |
| Protein Name / Synonyms | hMAD 2;hMAD-2;hSMAD2;JV18 1;JV18;JV18;JV18-1;JV181;MAD;MAD;MAD homolog 2;MAD Related Protein 2;Mad-related protein 2;MADH2;MADR2;MGC22139;MGC34440;Mothers Against Decapentaplegic Homolog 2;Mothers Against Decapentaplegic Homolog 2;mothers against DPP homolog 2;OTTHUMP00000163489;Sma and Mad related protein 2;SMAD 2;SMAD;SMAD family member 2;SMAD, mothers against DPP homolog 2;SMAD2;SMAD2_HUMAN. |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting, ICC |
| Research Area | Cardiovascular Disease, TGF-beta Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:500)
Western blot detection of Smad2 in Hela,A431,Jurkat and K562 cell lysates using Smad2 mouse mAb (1:500 diluted).Predicted band size:60KDa.Observed band size:60KDa.
ICC (1:100)
Immunocytochemistry staining of HeLa cells fixed with 1% Paraformaldehyde and using Smad2 mouse mAb (dilution 1:100).
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.