Purified His-tagged USP14 protein was used to produced this monoclonal antibody.
Human, Mouse, Rat
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
USP14 Antibody (N-term)(Cat# 102-10447) western blot analysis in K562,Jurkat cell line ,mouse brain abd rat brain tissue lysates (35ug/lane).This demonstrates the USP14 antibody detected the USP14 protein (arrow).
2-8°C (short-term); -20°C (long-term)
12 months from the date of shipment when stored properly.